[{"id":"ci_779f8611054fde7c5dfb27d43009b584acff688b155669b0ad201cba24fc90c9","title":"Preface","path":"/scientific-principles-guide/GPX.2/preface-scientific-principles-guide","children":[]},{"id":"ci_0cf18a45efee52a4337e20d1cfb5c20cde7186e29c736d2b581b5d6cf6b31e8c","title":"AssessmentsPlus™","path":"/scientific-principles-guide/GPX.2/prodigy","children":[]},{"id":"ci_438ef5e15a3f66af3cb5384f6724a5791744dbc477492affd7b9f6055f255e4f","title":"The Advanced Compartmental Absorption and Transit Model","path":"/scientific-principles-guide/GPX.2/the-advanced-compartmental-absorption-and-transit-","children":[{"id":"ci_6b222b6322b46c33c3270e58b3e2365a7ec5e832d5a154d74cb6674f6cb6ea7b","title":"ACAT Model Schematic","path":"/scientific-principles-guide/GPX.2/acat-model-schematic","children":[]},{"id":"ci_1b8107246a694fda177cc9ae182421c258badd7aa0cac19c91a34a1a8e1ab8f6","title":"Dynamic Fluid Volume Model","path":"/scientific-principles-guide/GPX.2/dynamic-fluid-volume-model","children":[]},{"id":"ci_d0a8d98e61b9767269716c2196937b2cb9f1fb46338f71985ac21ab4ba92eade","title":"Fed State Physiologies","path":"/scientific-principles-guide/GPX.2/fed-state-physiologies","children":[]},{"id":"ci_e5a43886ca6ce1be451812e60e685fabae4ec19f6abb84259c90861187e53619","title":"Absorption Modeling of In Vivo Drug Behavior","path":"/scientific-principles-guide/GPX.2/absorption-modeling-of-in-vivo-drug-behavior","children":[]},{"id":"ci_adb8415aafbc6f59fcc0af7452200268456730123291d3ded979154c5189cd0a","title":"Drug Release Dosage Forms","path":"/scientific-principles-guide/GPX.2/drug-release-dosage-forms","children":[]},{"id":"ci_c4c8b4818490b3edc6f5febca1549085c17fea093302dd5a3c829fc91d12b7e5","title":"Solubility and Dissolution Models","path":"/scientific-principles-guide/GPX.2/solubility-and-dissolution-models","children":[]},{"id":"ci_c0aa1bceea4c0f3ea24ecc96a606145e858642d1e000ea2b2411bc4686d3b653","title":"Precipitation Models","path":"/scientific-principles-guide/GPX.2/precipitation-models","children":[]},{"id":"ci_151c7b794758d4022cb8f5aac2a8d541560d288da7b1bf7d7ef812557fa2774a","title":"Lumenal Degradation","path":"/scientific-principles-guide/GPX.2/lumenal-degradation","children":[]},{"id":"ci_6b5e2707830f05eb279ff9013e2eab5095720870eba55f28950ccebb4a56237e","title":"Absorption Models","path":"/scientific-principles-guide/GPX.2/absorption-models","children":[]},{"id":"ci_56665a4bbbf1879be30d48774dcd87a38cc3317dca939cd4e824044727f318b2","title":"Saturable Metabolism in the GI Tract and Liver","path":"/scientific-principles-guide/GPX.2/saturable-metabolism-in-the-gi-tract-and-liver","children":[]},{"id":"ci_8196328aaeb79df3e6aef02c2da3875454e095c1aaed02e8c9e03701f7051d38","title":"ACATPlus™","path":"/scientific-principles-guide/GPX.2/acat","children":[]}]},{"id":"ci_ba95bcb4755915a3fba367a689c362fbc3150c44cee1f7a6b80847c39712ca5b","title":"Pharmacokinetics","path":"/scientific-principles-guide/GPX.2/pharmacokinetics","children":[{"id":"ci_f05b007daf702aa89420ca45b6e4e7a2fbc4dab44d91f06c52dfe6fd5ee42a47","title":"Introduction to Physiologically-Based Pharmacokinetics","path":"/scientific-principles-guide/GPX.2/introduction-to-physiologically-based-pharmacokine","children":[]},{"id":"ci_adb364f84c43a6636a7927351c647850166b2717ffd1ca0c5e46229e2a7a31d1","title":"Tissue Models for PBPK","path":"/scientific-principles-guide/GPX.2/tissue-models-for-pbpk","children":[]},{"id":"ci_b030753e38e30469fe4ac048c1eb759d6c47bb8b0c738516fffd18965802b3a4","title":"Tissue Types in a PBPK Model","path":"/scientific-principles-guide/GPX.2/tissue-types-in-a-pbpk-model","children":[]},{"id":"ci_9d6465e237bfa61df2ceb2863fe981ef87f1ffe14c92c433841135b468dafba4","title":"Tissue Distribution Calculations","path":"/scientific-principles-guide/GPX.2/tissue-distribution-calculations","children":[]},{"id":"ci_04339d41cf38c38b36c9596910768d8cf99ad9ea9040e30bc684e839c3cb8e39","title":"Kp Calculation Variable Assumptions","path":"/scientific-principles-guide/GPX.2/kp-calculation-variable-assumptions","children":[]},{"id":"ci_79019a94df9b7be8e854e7ef296d703e22469c673cc4f3f36713f2a0b6651edd","title":"Population Estimates for Age-Related Physiology","path":"/scientific-principles-guide/GPX.2/population-estimates-for-age-related-physiology","children":[]},{"id":"ci_813a4ad7f4cf9ecb1b7970ad1449992ce52b472ac9a3d1548ccf5996916fb532","title":"Compartmental Pharmacokinetics","path":"/scientific-principles-guide/GPX.2/compartmental-pharmacokinetics","children":[]}]},{"id":"ci_af2c236ac3d1ba771a308397ef4e6fdacf3c8eb49b029f920b45f0a9bcc1e87d","title":"Pharmacodynamics","path":"/scientific-principles-guide/GPX.2/pharmacodynamics","children":[{"id":"ci_05344ebe86a21a7e60938f27d614e9dc6cdba3467e97df1cfed7032288c28cb9","title":"Direct Response PD Models","path":"/scientific-principles-guide/GPX.2/direct-response-pd-models","children":[]},{"id":"ci_9f1dae56a669a021a1c7b66f8a24140288c0dff2ad51ffeccb0d25e29a0f0a87","title":"Indirect Response PD Models","path":"/scientific-principles-guide/GPX.2/indirect-response-pd-models","children":[]}]},{"id":"ci_130fbf9430c7f9dcad131321e55ecb5d2642295593b2127db5a63d528152cc26","title":"Drug-Drug Interaction Module","path":"/scientific-principles-guide/GPX.2/drug-drug-interaction-module","children":[{"id":"ci_01b128e17bfb7b10b03f02e81d640c6ead61d6d275f444cb1d793df6ed214c94","title":"DDI Module Overview","path":"/scientific-principles-guide/GPX.2/ddi-module-overview","children":[]},{"id":"ci_2e234ce01d0b64d4f29891ba990769c9457135a64afe6d859261c97246dd00da","title":"Steady State Calculations with the DDI Module","path":"/scientific-principles-guide/GPX.2/steady-state-calculations-with-the-ddi-module","children":[]},{"id":"ci_4a3e2fbb4e6caafecca7f1e96c0c97584346666de340f0560123faed87a0b593","title":"Dynamic Simulations with the DDI Module","path":"/scientific-principles-guide/GPX.2/dynamic-simulations-with-the-ddi-module","children":[]}]},{"id":"ci_12cc97200daf5cb347a42657047e5e770889198b606e786100faca47787e46d1","title":"In Vitro and In Vivo Correlation Plus Module","path":"/scientific-principles-guide/GPX.2/in-vitro-and-in-vivo-correlation-plus-module","children":[{"id":"ci_6450edb19f0279b33966a654082451951afc3e3c51cca77a94215be87f866c97","title":"IVIVC Benefits and Categories","path":"/scientific-principles-guide/GPX.2/ivivc-benefits-and-categories","children":[]},{"id":"ci_38528faab5c0a9c5cb454cfdec3f49d7c99d94c028345268373812c7c2b0ff7c","title":"Level A IVIVC Required Inputs and Established Steps","path":"/scientific-principles-guide/GPX.2/level-a-ivivc-required-inputs-and-established-step","children":[]},{"id":"ci_8b5b9704cdb1e4a0a2bf5d21cd7c692a723d8c78499e8f097d1c7e0126f70acd","title":"Level A IVIVC Deconvolution","path":"/scientific-principles-guide/GPX.2/level-a-ivivc-deconvolution","children":[]},{"id":"ci_b4a62c9b38f9a5701a082fd0315428eb4afd13f789efe7a402496342664061ab","title":"Level A IVIVC Validation","path":"/scientific-principles-guide/GPX.2/level-a-ivivc-validation","children":[]}]},{"id":"ci_55cb3bbd32b202708d0c269ca3c530843ce4720ee115de5ba345157ed3380671","title":"The Population Simulator Mode and Virtual Bioequivalence","path":"/scientific-principles-guide/GPX.2/the-population-simulator-mode-and-virtual-bioequiv","children":[{"id":"ci_16722394e44dc9da470ccd17ef7ec460bc98dbaf741943cc4bf00200165bc5d1","title":"Population Simulation Outputs Equations","path":"/scientific-principles-guide/GPX.2/population-simulation-outputs-equations","children":[]},{"id":"ci_4db50cdf45ed6c6c40e122122f1761f83acc6da2a43d539b527510a0cbca371f","title":"Virtual Bioequivalence","path":"/scientific-principles-guide/GPX.2/virtual-bioequivalence","children":[]}]},{"id":"ci_14432ce143dce038f8b3d4fd425198975aceb1b5496ebacf37f4be5705090316","title":"Additional Dosage Routes","path":"/scientific-principles-guide/GPX.2/additional-dosage-routes","children":[{"id":"ci_d6512d7c334f06720b3c19747ae443471ec98bc491539b3fd94e96a67948c4cf","title":"Intramuscular and Subcutaneous Compartments","path":"/scientific-principles-guide/GPX.2/im-and-subq","children":[]}]},{"id":"ci_d34c05a220b69105f403ddafc5557d3214c7dd03cabc3ea8b4a0f214ea4fd1e5","title":"Equation Standards","path":"/scientific-principles-guide/GPX.2/equation-standards","children":[{"id":"ci_8c0fd74bbe8a3b71cee50fff553c182b4651ccb34b772657a33a92956988cedd","title":"Internal Documentation Standards for GastroPlus® Equations","path":"/scientific-principles-guide/GPX.2/internal-documentation-standards-for-gastroplus-eq","children":[]}]},{"id":"ci_3845005cadf8bcd7d41f841fbba1542cc43d77bcbabf0d8c0926700adb8fcdb4","title":"Additional Suggested Reading","path":"/scientific-principles-guide/GPX.2/additional-references","children":[]}]