Tutorial: Overview of a GPX™ Project

Simulation

In GPX™, a simulation is the mechanistic modeling of the absorption, distribution, metabolism, and excretion (ADME) of a pharmaceutical compound (drug) within the context of the physiology of an organism. A simulation has both settings and configurations.

Assets

Each of the four phases of an ADME simulation in GPX™ consists of individual components called assets. The core assets in GPX™ are compound, formulation, dosing schedule, physiology, physiology schedule, and simulation. An asset is either an individual asset or a combined asset, which is an asset that requires multiple, reusable assets. For example, a simulation is a combined asset because it requires three individual, reusable assets: a compound asset, a dosing schedule asset, and a physiology schedule asset.

GPX™ project

In GPX™, a project is comprised of all the assets that are necessary for setting up the simulation, running the simulation, and then analyzing the simulation results. Settings control how assets are used in the simulation. Configurations control the computational set up of the simulation.