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Scientific Principles Guide

Getting Started
User Guide
Scientific Principles Guide
Equations Guide
Tutorials

Scientific Principles Guide

Main

Getting Started
User Guide
Scientific Principles Guide
Equations Guide
Tutorials

Main

Preface
AssessmentsPlus™

The Advanced Compartmental Absorption and Transit Model

ACAT Model Schematic
Dynamic Fluid Volume Model
Fed State Physiologies
Absorption Modeling of In Vivo Drug Behavior
Drug Release Dosage Forms
Solubility and Dissolution Models
Precipitation Models
Lumenal Degradation
Absorption Models
Saturable Metabolism in the GI Tract and Liver
ACATPlus™

Pharmacokinetics

Introduction to Physiologically-Based Pharmacokinetics
Tissue Models for PBPK
Tissue Types in a PBPK Model
Tissue Distribution Calculations
Kp Calculation Variable Assumptions
Population Estimates for Age-Related Physiology
Compartmental Pharmacokinetics

Pharmacodynamics

Direct Response PD Models
Indirect Response PD Models

Drug-Drug Interaction Module

DDI Module Overview
Steady State Calculations with the DDI Module
Dynamic Simulations with the DDI Module

In Vitro and In Vivo Correlation Plus Module

IVIVC Benefits and Categories
Level A IVIVC Required Inputs and Established Steps
Level A IVIVC Deconvolution
Level A IVIVC Validation

The Population Simulator Mode and Virtual Bioequivalence

Population Simulation Outputs Equations
Virtual Bioequivalence

Additional Dosage Routes

Intramuscular and Subcutaneous Compartments

Equation Standards

Internal Documentation Standards for GastroPlus® Equations

Additional Suggested Reading

Breadcrumbs

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PDF Documentation - Scientific Principles Guide

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