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Preface
AssessmentsPlus™
The Advanced Compartmental Absorption and Transit Model
ACAT Model Schematic
Dynamic Fluid Volume Model
Fed State Physiologies
Absorption Modeling of In Vivo Drug Behavior
Drug Release Dosage Forms
Solubility and Dissolution Models
Precipitation Models
Lumenal Degradation
Absorption Models
Saturable Metabolism in the GI Tract and Liver
ACATPlus™
Pharmacokinetics
Introduction to Physiologically-Based Pharmacokinetics
Tissue Models for PBPK
Tissue Types in a PBPK Model
Tissue Distribution Calculations
Kp Calculation Variable Assumptions
Population Estimates for Age-Related Physiology
Compartmental Pharmacokinetics
Pharmacodynamics
Direct Response PD Models
Indirect Response PD Models
Drug-Drug Interaction Module
DDI Module Overview
Steady State Calculations with the DDI Module
Dynamic Simulations with the DDI Module
In Vitro and In Vivo Correlation Plus Module
IVIVC Benefits and Categories
Level A IVIVC Required Inputs and Established Steps
Level A IVIVC Deconvolution
Level A IVIVC Validation
The Population Simulator Mode and Virtual Bioequivalence
Population Simulation Outputs Equations
Virtual Bioequivalence
Additional Dosage Routes
Intramuscular and Subcutaneous Compartments
Equation Standards
Internal Documentation Standards for GastroPlus® Equations
Additional Suggested Reading
Getting Started
User Guide
Scientific Principles Guide
Equations Guide
Tutorials
Scientific Principles Guide
PDF Documentation - Scientific Principles Guide
Documentation
Preface
AssessmentsPlus™
The Advanced Compartmental Absorption and Transit Model
ACAT Model Schematic
Dynamic Fluid Volume Model
Fed State Physiologies
Absorption Modeling of In Vivo Drug Behavior
Drug Release Dosage Forms
Solubility and Dissolution Models
Precipitation Models
Lumenal Degradation
Absorption Models
Saturable Metabolism in the GI Tract and Liver
ACATPlus™
Pharmacokinetics
Introduction to Physiologically-Based Pharmacokinetics
Tissue Models for PBPK
Tissue Types in a PBPK Model
Tissue Distribution Calculations
Kp Calculation Variable Assumptions
Population Estimates for Age-Related Physiology
Compartmental Pharmacokinetics
Pharmacodynamics
Direct Response PD Models
Indirect Response PD Models
Drug-Drug Interaction Module
DDI Module Overview
Steady State Calculations with the DDI Module
Dynamic Simulations with the DDI Module
In Vitro and In Vivo Correlation Plus Module
IVIVC Benefits and Categories
Level A IVIVC Required Inputs and Established Steps
Level A IVIVC Deconvolution
Level A IVIVC Validation
The Population Simulator Mode and Virtual Bioequivalence
Population Simulation Outputs Equations
Virtual Bioequivalence
Additional Dosage Routes
Intramuscular and Subcutaneous Compartments
Equation Standards
Internal Documentation Standards for GastroPlus® Equations
Additional Suggested Reading
Scientific Principles Guide